The impact of Silymarin on improvement of platelet abnormalities in patients with severe preeclampsia

نویسندگان

  • Fahimeh Kaveh Baghbahadorani
  • Sepideh Miraj
چکیده

BACKGROUND Preeclampsia is a pregnancy-specific disorder that is associated with an increase in blood pressure and proteinuria; in severe cases, it can cause platelet abnormalities. Silymarin is the extract of Silybum marianum, which is recognized as a safe antioxidant drug. OBJECTIVE To determine the impact of Silymarin on the improvement of severe preeclampsia in 60 patients with severe preeclampsia. METHODS In this double-blind clinical trial study, This study included 60 patients whose pregnancies were terminated because of severe preeclampsia and who were referred to Hajar Hospital in Shahrekord, Iran, from April 2014 to September 2015. The patients were divided randomly into two groups, i.e., a group of 30 patients and a control group of 30 patients. In addition to the current treatments for preeclampsia, The members of the study group were administered 70 mg of Silymarin at three hours and 24 hours after the termination of their pregnancies. The control group received a placebo at the same times. Platelet count tests were compared at the baseline and at 12, 36, and 60 hours post-measurements in the two groups by SPSS software, version 22, by the ANOVA test, and by the independent-samples t-test. RESULTS At the baseline, the two groups were not significantly different in terms of various criteria, such as age, BMI, and platelet counts. There were no significant differences between the two groups regarding the number of platelets at 12, 36, and 60 h after their pregnancies were ended (p > 0.01). CONCLUSIONS The results of this study indicated that, although oxidative factors are involved in the incidence of complications of preeclampsia, e.g., thrombocytopenia, merely using an oxidative agent does not alleviate this effect. This indicated that other factors likely are involved in the pathogenesis of this disease. Additional studies are needed to prove the beneficial effects of this drug in the treatment of preeclampsia. CLINICAL TRIAL REGISTRATION The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT201509042388/N1. FUNDING Shahrekord University of Medical Sciences supported this research (project no. 2006).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Impact of Silymarin on Improvement of Hepatic Abnormalities in Patients with Severe Preeclampsia: A Randomized Clinical Trial

BACKGROUND Preeclampsia is a pregnancy-specific disorder, associated with increased blood pressure and proteinuria, and in extreme cases it can also cause liver and kidney problems. OBJECTIVE To determine the impact of silymarin on the improvement of severe preeclampsia. METHODS This randomized clinical trial was conducted at Hajar Hospital in Shahrekord, Iran, from April 2014 to September ...

متن کامل

Hyperuricemia and Perinatal Outcomes in Patients with Severe Preeclampsia

Maternal, fetal and neonatal complications are correlated with hypertensive disorders during pregnancy.  In this context, the maternal blood uric acid level is reported to be one of the prognostic factors in determining the prenatal outcome.  Based on the existing data, the present descriptive study was performed on two groups of women with severe preeclampsia; the first group (n=53) with a uri...

متن کامل

Early preeclampsia and HELLP syndrome in a 20 week pregnant patient

 The first time Weinstein in 1982 described patients with the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP) in pregnant preeclamptic and eclamptic patients. This syndrome is a severe form of preeclampsia or eclampsia. Usually HELLP syndrome occurs at the third trimester and only 15% occur before the 27th week of pregnancy and rarely before the 20th week of pregna...

متن کامل

بررسی ارتباط سطح سرمی N-terminal Pro-brain Natriuretic Peptide و شدت پره‌اکلامپسی

Background and purpose: Preeclampsia is a serious condition in pregnancy. Previous studies have shown that NT-pro BNP level is higher in preeclamptic patients than that in pregnant women with normal blood pressure. Severity of preeclampsia is one of the critical factors in managing patients, so, this study aimed at investigating the relationship between the level of NT-pro BNP and severity of ...

متن کامل

مقایسه سطح تروپونین I در زنان مبتلا به پره اکلامپسی و فشارخون بارداری با زنان باردار با فشار خون نرمال

Background and purpose: Hypertensive disorders of pregnancy are still one of the major issues in obstetrics. So far, few studies are conducted on the troponin I level of pregnant women and preeclampsia but their results are not conclusive. In this study the troponin levels were compared between patients with severe preeclampsia, mild preeclampsia, gestational hypertension, and normal blood pres...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2016